Time-resolved structural studies of membrane proteins at synchrotrons and X-ray free electron lasers: opportunities and challenges
by Professor Richard Neutze, University of Gothenburg
Tuesday 30th April
Auditorium 2, Ørsted Institute, Universitetsparken 5,
Conformational dynamics are essential to the correct functioning of virtually all macromolecules expressed in the cell: all reactions involve atomic motion. Although X-ray crystallography has been applied with great success to solve the majority of known macromolecular structures, this method is static: it reveals a structure averaged in both time and space over the numerous conformations of a macromolecule within the crystal.
A key focus of Neutzes group is to develop approaches for investigating dynamics of membrane proteins, with a time-resolution down to picoseconds. In order to reach this goal the group is a heavy user of large international synchrotron and X-ray free electron laser facilities. In his talk, Neutze will present recent results and discuss challenges with the approach.