Søren Roi Mitgaard – University of Copenhagen

Søren Roi Mitgaard


The Structural Biophysics Group
Niels Bohr Institute
Faculty of Science


Søren R. Midtgaard studies the properties of lipoprotein particles. Both how the traditional discoidal ApoA1 based discs are assembled and also how to make new novel discs. Furthermore, since these discs are potentially good tools for stabilizing membrane proteins, a substantial part of his research is also focused on how to optimally stabilize membrane proteins in lipoprotein particles.

It is a very interdisciplinary center and spans a broad range of classic research areas. This gives me the possibility to interact with people with many different backgrounds. It also gives me a large network of people to collaborate with when a new idea has to be tested that requires skills found in other labs.

Collaborations within the Center for Synthetic Biology
Knud J. Jensen
Lise Arleth
Kell Mortensen
Poul Erik Jensen
Anja Fuglsang
Marité Cardenas
Karen Martinez


2013-present Postdoc, Structural Biophysics Group, Niels Bohr Institute, University of Copenhagen
2009-2013 PhD thesis: De novo design of nanodisc belts, The Structural Biophysics Group, Niels Bohr Institute, Faculty of Science
2011 Visiting Scholar, University of Michigan (5 months)
2006-2009 MSc, Nanotechnology, Protein Crystallography, Aarhus University
2003-2006 BSc, Nanotechnology, Aarhus University

Scientific Publications
Midtgaard, S.R., Pedersen, M.C., Kirkensgaard, J.J.K., Sorensen, K.K., Mortensen, K., Jensen, K.J, Arleth, L Self-assembling peptides form nanodiscs that stabilize membrane proteins. Soft Matter 10(5):738-752, doi:10.1039/c3sm51727f (2014).

Kynde, S.A.R., Skar-Gislinge, N., Pedersen, M.C., Midtgaard, S.R., Simonsen, J.B., Schweins, R., Mortensen, K., Arleth, L. Small-angle scattering gives direct structural information about a membrane protein inside a lipid environment Acta Crystallographica. Section D: Biological Crystallography 70(2):371-383, doi:10.1107/S1399004713028344 (2014).

Maric, S., Skar-Gislinge, N., Midtgaard, S., Thygesen, M.B., Schiller, J., Frielinghaus, H., Moulin, M., Haertlein, M., Forsyth, V.T., Günther-Pomorski, T., Arleth, L. Stealth carriers for low-resolution structure determination of membrane proteins in solution. Acta Crystallographica. Section D: Biological Crystallography 70(2):317-328, doi:10.1107/S1399004713027466 (2014)

Wadsäter, M.H., Cardenas Gomez, M., Rønholt, S., Maric, S., Skar-Gislinge, N., Midtgaard, S.R., Arleth, L., Mortensen, K., Ryan, R.O., Simonsen, J.B. Lipid-protein interactions in nanodiscs: how to enhance stability. Biophysical Journal 102(3):236a., doi:10.1016/j.bpj.2011.11.1299 (2012).