Seminar: Allosteric modulation of GPCRs – University of Copenhagen

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Seminar: Structural insights into allosteric modulation of GPCRs

By Christine Oswald, Senior Scientist at Heptares Therapeutics Ltd, UK

When: 10-12, February 8th
Where: M117, Thorvaldsensvej 40, 1st. fl.

Abstract: G protein-coupled receptors (GPCRs) regulate a range of physiological processes and thus they are extremely interesting as drug target.   Heptares’ proprietary StaR® technology is very valuable for the thermostabilisation of GPCRs in a chosen conformational state. This process generates thermostabilised StaR® protein that can be readily solubilised with detergent, purified and utilised for further applications such as biophysical screening techniques and structure determination via X-ray crystallography.   Recently, the usage of StaR® technology at Heptares Therapeutics Ltd. enabled the determination of structures from various GPCRs bound to their respective allosteric modulators. Here, I present structural insight into allosteric modulation of different GPCRs

Christine Oswald CV:

If you have any questions, contact: Nanna Heinz: