Dimitrios Stamou – University of Copenhagen

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Center for Synthetic Biology > Meet the Researchers > Dimitrios Stamou

Dimitrios Stamou

Professor

Bio-nanotechnology and Nanomedicine Group
Department of Chemistry
Faculty of Science
stamou@nano.ku.dk






Dimitrios Stamou's main research interest is the spatio-temporal organization of biological systems on the nanoscale and its impact on normal and aberrant biological functions.

Research
In particular, we study a variety of different biological systems with the objective to identify unifying biophysical mechanisms that control on the nanometer scale the structure and function of proteins and membranes. Such mechanisms lead to the emergence of new rules of regulation of biochemical reactions and signal transduction networks that transcend classical bi-molecular (e.g. receptor-ligand) interactions.

By harnessing expertise on self-assembly and quantitative microscopy, we aim to to develop prototypic biosensing nanoscale platforms and zeptolitre fluidic devices for applications in screening and diagnostics.

One of the major objectives of our group in the coming decade is to identify and characterize in a quantitative manner the multiple instances during which the shape of cellular membranes dictates the outcome of biological processes.

 

 

 

 

 

 

CV

2010-2015 Director of Lundbeck Foundation Center of Excellence Biomembranes in Nanomedicine (Co–directing with Ulrik Gether).
2010-present Professor MSO. Department of Neuroscience and Pharmacology,UniversityofCopenhagen, DK.
2006-present  Head of Bio-Nanotechnology and Nanomedicine Laboratory Department of Neuroscience and Pharmacology & Nano-Science Center, University of Copenhagen, DK.
2006-2010 Associate Professor, Department of Neuroscience and Pharmacology & Nano-Science Center, University of Copenhagen, DK.
2004-2006  Assistant Professor, Department of Neuroscience and Pharmacology & Nano-Science Center, University of Copenhagen, DK.
2002-2004  Group Leader, Ecole Polytechnique Fédéral de Lausanne,CH.
2000-2002 Postdoctoral Fellow, Ecole Polytechnique Fédéral de Lausanne,CH.
1996-2000  Ph.D. Physical Chemistry, Ecole Polytechnique Fédéral de Lausanne with Prof. H. Vogel,CH.
1992-1995 B.Sc. Hon. Physics, Awarded grade: A−,Leeds University,UK

Collaborations within the Center for Synthetic Biology
Ulrik Gether
Søren Rasmussen
Thomas Pomorski
Lise Arleth
Karen Martinez
Poul Erik Jensen
Claus Løland
Knud J. Jensen
Nikos Hatzakis

Selected Scientific Publications
Larsen, J.B., Jensen, M.B., Bhatia, V.K., Pedersen, S.L., Bjørnholm, T., Iversen, L., Uline, M., Szleifer, I., Jensen, K.J., Hatzakis, N.S., Stamou, D. Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases. Nature Chemical Biology, (2014) in press.                                           

Mathiasen, S., Christensen, S.M., Fung, J.J., Rasmussen, S.G.F., Fay, J.F., Jørgensen, S.K., Veshaguri, S., Farrens, D.L., Kiskowski, M., Kobilka, B., Stamou, D. Nanoscale high-content analysis using compositional heterogeneities of single proteoliposomes. Nature Methods 11, 931-934, doi:10.1038/nmeth.3062 (2014). I.F. 20,721

Iversen, L. Tu, H.-L., Lin, W.-C., Christensen, S.M., Abel, S.M., Iwig, J., Wu, H.-J., Gureasko, J., Rhodes, C., Petit, R.S., Hansen, S.D., Thill, P., Yu, C.-H., Stamou, D. Chakraborty, A.K., Kuriyan, J., Groves, J.T. Ras activation by SOS: Allosteric regulation by altered fluctuation dynamics. Science 345, 50-54, doi:10.1126/science.1250373(2014). I.F.34,463

Tonnesen, A., Christensen, S. M., Tkach, V. & Stamou, D. Geometrical Membrane Curvature as an Allosteric Regulator of Membrane Protein Structure and Function. Biophysical J. 106, 201-209, doi:10.1016/j.bpj.2013.11.023 (2014). I.F. 4,218

Christensen, S.M., Bolinger, P.Y., Hatzakis, N.S., Mortensen, M.W., Stamou, D. Mixing sub-attolitre volumes in a quantitative and highly parallel manner with soft matter nanofluidics. Nature Nanotechnology 7 (1): 51–55, doi:10.1038/nnano.2011.185 (2012).

Jensen, M.B., Bhatia, V.K., Jao, C.C., Rasmussen J.E., Pedersen, S.L., Jensen K.J., Langen, R., Stamou,D. Membrane Curvature Sensing by Amphipathic Helices: A single liposome study using a-synuclein and annexin B12. Journal of Biological Chemistry 286, 42603-42614, doi:10.1074/jbc.M111.271130 (2011).

Madsen, K.L., Bhatia, V.K., Gether, U., Stamou, D. BAR Domains, Amphipathic Helices and Membrane-Anchored Proteins use the same mechanism to sense membrane curvature. FEBS Letters 584:1848-1855, doi:10.1016/j.febslet.2010.01.053(2010).

Hatzakis, N.S., Bhatia, V. K., Larsen, J., Madsen, K.L.,Bolinger, P.Y., Kunding, A. H., Castillo, J., Gether, U., Hedegård, P., Stamou, D. How Curved Membranes Recognize Amphipathic Helices and Protein Anchoring Motifs. Nature Chemical Biology 5 (11): 835-841, doi:10.1038/nchembio.213 (2009).

Bhatia, V.K., Madsen, K. L., Bolinger, P.Y, Hedegård, P., Gether, U., Stamou, D. Amphipathic motifs in BAR domains are essential for membrane curvature sensing. EMBO Journal, 28 (21):3303-3014, doi:10.1038/emboj.2009.261(2009).

Bendix, P.M., Pedersen, M.S., Stamou, D. Quantification of nano-scale intermembrane contact areas using fluorescence resonance energy transfer. Proceedings of the National Academy of Sciences USA 106 (30):12341-12346, doi:10.1073/pnas.0903052106 (2009).