Bo Wegge Laursen – University of Copenhagen

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Center for Synthetic Biology > Meet the Researchers > Bo Wegge Laursen

Bo Wegge Laursen

Professor

Member of the Steering Group
Head of the Nano Science Center
Nano and Materials Chemistry Group
Department of Chemistry
Faculty of Science
bwl@nano.ku.dk

Bo W. Laursen's group designs and synthesizes new organic fluorescent molecules with potential applications as: molecular sensors, self-assembling nano materials, active components in opto-electronic devices.

Research
Our core activities include: molecular design, organic synthesis, UV-Vis and fluorescence spectroscopy and microscopy, structural studies of thin films and aggregates using Langmuir Blodgett techniques, AFM and X-ray diffraction and reflectometry.
The design and synthesis of new fluorescent organic molecules is of major importance for the development bio imaging, bio-sensors and diagnostic methods used in drug development and all areas of bio and nano science.

Recent examples of research projects in the above mentioned fields are:
Dyes
Sørensen, T.J., Thyrhaug, E., Szabelski, M., Luchowski, R., Gryczynski, I., Gryczynski, Z. and Laursen, B.W. Azadioxatriangulenium: a long fluorescence lifetime fluorophore for large biomolecule binding assay. Methods Appl. Fluorescence 1, 025001 (6pp), doi:10.1088/2050-6120/1/2/025001 (2013).

Westerlund, F., Hildebrandt, C.B. , Sørensen, T.J. and Laursen, B.W. Trihydroxytrioxatriangulene - An Extended Fluorescein and a Ratiometric pH Sensor. Chemistry: A European Journal 16(10), 2992 – 2996, doi:10.1002/chem.200902965 (2010).

Self-assembly
Shi, D., Schwall, C., Sfintes, G., Thyrhaug, E., Hammershøj, P., Cárdenas, M., Simonsen, J.B., Laursen, B.W. Counterions control whether self-assembly leads to formation of stable and well-defined unilamellar nanotubes or nanoribbons and nanorods. Chemistry – A European Journa 20, 6853-6856, doi:10.1002/chem.201402523 (2014).

Shi, D., Sfintes, G., Laursen, B.W., Simonsen, J.B. Fluorescent and highly stable unimodal DMPC based unilamellar vesicles formed by spontaneous curvature. Langmuir 28, 8608−8615, doi:10.1021/la301454y (2012).

Molecular electronics
Li, T., Hauptmann, J.R., Wei, Z., Petersen, S., Bovet, N., Vosch, T., Nygård, J., Hu, W., Liu, Y., Bjørnholm, T., Nørgaard, K., Laursen, B.W. Solution-Processed Ultrathin Chemically Derived Graphene Films as Soft Top Contacts for Solid-State Molecular Electronic Junctions. Advanced Materials 24, 1333–1339, doi:10.1002/adma.201104550 (2012).

Figure: Addition of 5 mol% of the amphiphilic fluorescent dye Na-DSA to phospholipid DMPC result in selective formation of unimodal highly stable unilamellar vesicles. 

CV

2013-present Director of Nano-Science Center, University of Copenhagen
2013-present Professor of Chemistry, University of Copenhagen
2010-present Research group leader for the Nano and Materials Chemistry group at Institute of Chemistry, KU, with 6 faculty members and app. 40 post docs, PhD, and M. Sc. students.
2009-present Project manager on Chinese Danish Center for Self-assembled molecular electronic nanosystems, a +30 milion DKK research program between Nano-Science Center at University of Copenhagen and Chinese Academy of Science.
2009-2013 Associate professor, Department of Chemistry, University of Copenhagen. Permanent position.
2006-2009 Research associate professor with the Nano-Science Center Department of Chemistry, University of Copenhagen. Three-year Skou grant by the Danish Natural Science Research Council (FNU).
2004-2006 Research assistant professor with the Nano-Science Center, Department  of Chemistry, University of Copenhagen. A two-year talent project funded by the Danish Technical Research Council (STVF).
2003-2004 Post Doctoral fellow in the group of Professor J. F. Stoddart at University of California, Los Angeles. Funded by the Danish Natural Science Research Council (FNU) and California Nano System Institute (CNSI).
2001-2003 Post Doctoral position at the Nano-Science Center, Department of Chemistry, University of Copenhagen, in the group of Professor Thomas Bjørnholm. Project: EU Growth project, DISCEL: “Self-Assembling and Self-Healing Electronic Devices Based on Mesoscopic Materials”.
1998-2001 Ph.D. from University of Copenhagen, work carried out at Risø National Laboratory, Department of Condensed Matter Physics and Chemistry, supervised by Professor Klaus Bechgaard (Risø) and Niels Harrit (University of Copenhagen).
1991-1997 B.Sc. and Master of Science in chemistry from University of Copenhagen.


Collaborations within the Center for Synthetic Biology
Tom Vosch
Marité Cárdenas
Jens B. Simonsen

Selected Scientific Publications
Shi, D., Schwall, C., Sfintes, G., Thyrhaug, E., Hammershøj, P., Cárdenas, M., Simonsen, J.B., Laursen, B.W. Counterions control whether self-assembly leads to formation of stable and well-defined unilamellar nanotubes or nanoribbons and nanorods. Chemistry – A European Journa 20, 6853-6856, doi:10.1002/chem.201402523 (2014).

Petersen, S., He, Y., Lang, J., Pizzocchero, F., Bovet, N., Bøggild, P., Hu, W. and Laursen, B.W. Stepwise reduction of immobilized monolayer graphene oxides. Chemistry of Materials 25 (24), 4839–4848, doi:10.1021/cm4015942 (2013).

Li, T., Jevric, M., Hauptmann, J.R., Hviid, R., Wei, Z., Wang, R., Reeler, N.E.A., Thyrhaug, E., Petersen, S., Meyer, J.A.S., Bovet, N., Vosch, T., Nygård, J., Qui, X., Hu, W., Liu, Y., Solomon, G.C., Kjærgaard, H.G., Bjørnholm, T., Nielsen, M.B., Laursen, B.W.*, Nørgaard, K.* Ultrathin Reduced Graphene Oxide Films as Transparent Top-Contacts for Light Switchable Solid-State Molecular Junctions”, Advanced Materials 25, 4164–4170, doi:10.1002/adma.201300607 (2013).

Westerlund, F., Lemke, H., Hassenkam, T., Simonsen, J., Laursen, B.W. Self-Assembly and Near Perfect Macroscopic Alignment of Fluorescent Triangulenium Salt in Spin Cast Thin Films on PTFE Langmuir 29,  6728-6736, doi:10.1021/la400797b (2013).

Sørensen, T.J., Thyrhaug, E., Szabelski, M., Luchowski, R., Gryczynski, I., Gryczynski, Z. and Laursen, B.W. Azadioxatriangulenium: a long fluorescence lifetime fluorophore for large biomolecule binding assay. Methods Appl. Fluorescence 1, 025001 (6pp), doi:10.1088/2050-6120/1/2/025001 (2013).

Thyrhaug, E., Sørensen, T., Gryczynski, I., Gryczynski, Z., Laursen, B.W. Polarization and Symmetry of Electronic Transitions in Long Fluorescence Lifetime Triangulenium Dyes. The Journal of Physical Chemistry A 117, 2160-2168, doi:10.1021/jp312376k (2013).

Rich, R.M., Stankowska, D.L., Maliwal, B.P., Laursen, B.W., Krishnamoorthy, R.R., Gryczynski, Z., Borejdo, J., Gryczynski, I., Fudala, R. Elimination of autofluorescence background from fluorescence tissue images using time-gated detection with AzaDiOxaTriAngulenium (ADOTA) fluorophore. Analytical & Bioanalytical Chemistry 405, 2065-2075, doi:10.1007/s00216-012-6623-1 (2013).

Petersen, S., Glyvradal, M., Bøggild, P., Hu, W., Feidenhans´l, R. and Laursen, B.W. Graphene Oxide as a Mono Atomic Blocking Layer. ACS Nano 6, 8022–8029, doi:10.1021/nn302628q (2012).

Hammershøj, P., Sørensen, T.J., Han, B.-H., Laursen, B.W. Base Assisted One-Pot Synthesis of N,N’,N’’-triaryltriazatriangulenium Dyes – Enhanced Fluorescence Efficiency by Steric Constraints. Journal of Organic Chemistry 77, 5606-5612, doi:10.1021/jo3007732 (2012).  

Shi, D., Sfintes, G., Laursen, B.W., Simonsen, J.B. Fluorescent and highly stable unimodal DMPC based unilamellar vesicles formed by spontaneous curvature. Langmuir 28, 8608−8615, doi:10.1021/la301454y (2012).

Chen, Q., Luo, M., Hammershøj, P., Zhou, D., Han, Y., Laursen, B.W., Yan, C.-G., Han, B.-H. Microporous Polycarbazole with High Specific Surface Area for Gas Storage and Separation. Journal of the American Chemical Society 134, 6084-6087, doi:10.1021/ja300438w (2012).  

Li, T., Hauptmann, J.R., Wei, Z., Petersen, S., Bovet, N., Vosch, T., Nygård, J., Hu, W., Liu, Y., Bjørnholm, T., Nørgaard, K., Laursen, B.W. Solution-Processed Ultrathin Chemically Derived Graphene Films as Soft Top Contacts for Solid-State Molecular Electronic Junctions. Advanced Materials 24, 1333–1339, doi:10.1002/adma.201104550 (2012).

Sørensen, T.J., Hildebrandt, C.B., Elm, J., Andreasen, J.W., Madsen A.Ø., Westerlund, F., Laursen, B.W. Large area, soft crystalline thin films of N,N’,N’’-trialkyltriazatriangulenium salts with homeotropic alignment of the discotic cores in a lamellar lattice. Journal of Materials Chemistry 22 (11), 4797–4805, doi:10.1039/C2JM15954F (2012).

Simonsen, J.B. , Westerlund, A.R.F. , Breiby, D.W. , Harrit, N.H. and Laursen, B.W. Columnar self-assembly and alignment of planar carbenium ions in langmuir-blodgett films. Langmuir  27(2), 792-799, doi:10.1021/la103785z (2011).

Westerlund, F., Hildebrandt, C.B. , Sørensen, T.J. and Laursen, B.W. Trihydroxytrioxatriangulene - An Extended Fluorescein and a Ratiometric pH Sensor. Chemistry: A European Journal 16(10), 2992 – 2996, doi:10.1002/chem.200902965 (2010).

Sørensen, T.J. and Laursen, B.W. Synthesis and Optical Properties of Trioxatriangulenium Dyes with One and Two Peripheral Amino Substituents. Journal of Organic Chemistry 75(18), 6182–6190, doi:10.1021/jo1009917 (2010).

Hansen, C.R. , Sørensen, T.J. , Glyvradal, M., Larsen, J., Eisenhardt, S.H. , Bjørnholm, T., Nielsen, M.M. , Feidenhans'l, R.K. and Laursen, B.W. Structure of the Buried Metal-Molecule Interface in Organic Thin Film Devices. Nano Letters 9, 1052–1057, doi:10.1021/nl803393m (2009).

Laursen, B.W. and Sørensen, T.J. Synthesis of Super Stable Triangulenium Dye. Journal of Organic Chemistry 74(8), 3183-3185, doi:10.1021/jo9002486 (2009).

Simonsen, J.B. , Kjær, K., Howes, P., Nørgaard, K. , Bjørnholm, T., Harrit, N.H. and Laursen, B.W. Close Columnar Packing of Triangulenium Ions in Langmuir Films. Langmuir 25(6), 3584-3592, doi:10.1021/la803733s (2009).

Sørensen, T.J. , Laursen, B.W. , Luchowski, R., Shtoyko, T., Akopova, I., Gryczynski, Z. and Gryczynski, I. Enhanced fluorescence emission of Me-ADOTA + by self-assembled silver nanoparticles on a gold film ' Chemical Physics Letters  476(1-3), 46-50, doi:10.1016/j.cplett.2009.05.064 (2009).