Towards quantitative investigations of GPCRs in an isolated system

PhD defense by Randi Westh Hansen

Academic supervisor: Karen L. Martinez

Abstract: G-protein coupled receptors (GPCRs) are the main mediators of cell signaling and are therefore important drug targets. Accordingly it is important to understand how cellular responses are controlled by GPCRs. The aim of my thesis was to isolate a GPCR from the complex cellular environment, and stabilized the biological function in an isolated system. The stabilized receptor was used for the development of sensitive assays towards quantifying the biological interactions of the first key events of GPCR signaling.

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